News & HighlightsNews
Programming the immune system to manufacture its own therapeutic proteins
By editing blood stem cells, researchers show that the immune system itself can be transformed into a durable, boostable source of therapeutic proteins—opening the door to potential single-shot treatments for diseases ranging from HIV to cancer.
Microtubules discovered to play an active role in correctly distributing chromosomes during cell division
Long thought to serve as cellular scaffolding, microtubules also reshape the proteins that bind to them—guiding enzyme activity to prevent genetic errors linked to cancer.
The color of your fat could determine the level of your blood pressure
Scientists knew that obesity raises the risk of hypertension. Now Paul Cohen's team has uncovered the mechanism—and the enzyme—that explains how fat can stiffen blood vessels and drive blood pressure upward.
How beige fat keeps blood pressure in check
New study shows that beige fat suppresses an enzyme that promotes high blood pressure, revealing a new molecular pathway and a potential target for future precision therapies.
New engineered derivative of a natural molecule could translate into a powerful replacement for IVIG therapy for a wide array of autoimmune disorders
In experiments with mice, the new molecule accomplished the same job at a hundredth of the dose.
What these scientists revealed about the structure of the T cell receptor could help resolve a decades-old debate over how T cells get activated
Researchers discovered new characteristics of a T cell receptor that’s essential to a variety of cutting-edge T cell immunotherapies.
This new insight into T cell receptors may improve cancer immunotherapies
Researchers discovered that a crucial first step in the signaling system operates differently than previously thought, an insight that could lead to the next generation of treatments.
Scientists can finally answer an old question about cellular aging
Replicative aging of human cells, the result of telomere shortening, is slower at physiological oxygen than at atmospheric oxygen, a difference now shown to be due to low oxygen impairing the ATM kinase response to withered telomeres.
Researchers develop a potential IVIG replacement for treating autoimmunity that’s significantly more potent
The discovery could greatly improve patient experience and address supply shortages.
Increasing levels of the protein PI31 demonstrates neuroprotective effects in mice
Boosting PI31 has been shown to head off Parkinson’s-like disorders and extend lifespan in fruit flies and mice, pointing to a possible new therapeutic target for treating rare neurodegenerative diseases, as well as more common disorders, such as Alzheimer's.
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