News & HighlightsNews
Study in fruit flies reveals a gene affecting the ability to sleep
On the surface, it’s simple: when night falls, our bodies get sleepy. But behind the scenes, a series of complex molecular events, controlled by our genes, is hard at work to make us groggy. Now, research suggests that a newly identified gene known as insomniacÌýmay play a role in keeping us aslee...
Nature Genetics: January 22, 2012
Nature Genetics online: January 22, 2012 Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis Paul Delgado-Olguín,ÌýYu Huang,ÌýXue Li,ÌýDanos Christodoulou,ÌýChristine E. Seidman,ÌýJ.G. Seidman,ÌýAlexander TarakhovskyÌýandÌýBenoit G. Bru...
Cell Stem Cell: January 6, 2012
Cell Stem Cell 10: 63–75 Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Naoki Oshimori and Elaine Fuchs Hair follicle (HF) regeneration begins when communication between quiescent epithelial stem cells (SCs) and underlying mesenchymal d...
Nature Immunology: December 25, 2011
Nature Immunology online: December 25, 2011 B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen Irene Puga, Montserrat Cols, Carolina M. Barra, Bing He, Linda Cassis, Maurizio Gentile, Laura Comerma, Alejo Chorny, Meimei Shan...
Cell 147: 1615–1627 (December 23, 2011)
Cell 147: 1615–1627 The functional organization of cutaneous low-threshold mechanosensory neurons Lishi Li, Michael Rutlin, VictoriaÌýE. Abraira, Colleen Cassidy, Laura Kus, Shiaoching Gong, MichaelÌýP. Jankowski, Wenqin Luo, Nathaniel Heintz, H.ÌýRichard Koerber, C.ÌýJeffery Woodbury andÌýÌýDavid...
Science 344: 1675-1680
Science 344: 1675–1680 How a DNA polymerase clamp loader opens a sliding clamp Brian A. Kelch, Debora L. Makino, Mike O’Donnell and John Kuriyan We present structures for the ATP-bound state of the clamp loader complex from bacteriophage T4, bound to an open clamp and primer-template DNA. The s...
In the News -- NYT
"But the rule against posthumous awards has now been violated several times — most recently this month, when the prize in medicine was given to the widow of Dr. Ralph M. Steinman, a scientist at Rockefeller University in Manhattan whoÌýdied of pancreatic cancer at age 68 on Sept. 30, three days be...
In the News -- NYT
"But the rule against posthumous awards has now been violated several times — most recently this month, when the prize in medicine was given to the widow of Dr. Ralph M. Steinman, a scientist at Rockefeller University in Manhattan whoÌýdied of pancreatic cancer at age 68 on Sept. 30, three days be...
In cancer, molecular signals that recruit blood vessels also trigger metastasis
Cancer cells are most deadly when they’re on the move — able not only to destroy whatever organ they are first formed in, but also to create colonies elsewhere in the body. New research has now shown how a small RNA prevents the recruitment and formation of blood vessels near cancer cell destine...
Nature online: December 14, 2011
Nature online: December 14, 2011 A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells Kim J. Png, Nils Halberg, Mitsukuni Yoshida and Sohail F. Tavazoie Here we reveal that endogenous miR-126, an miRNA silenced in a variety of common human cancers, non-cell-auto...
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