News & HighlightsNews
Structural images shed new light on a cancer-linked potassium channel
Ěý Ěý Most cells in the body carry on their surface tiny pores through which potassium ions travel. In controlling the flow of these positively charged ions, the channel helps the cell maintain its electrical balance. One particular type of potassium channel, called Eag1, has been found...
New antibody drug continues to show promise for treatment of HIV
Great strides have been made in recent years to develop treatment options for HIV, and the disease can now be controlled with anti-retroviral drugs. But a cure remains elusive and current medications have limitations: they must be taken daily, for life, and can cause long-term complications. Now,...
Resistance to antidepressants linked to metabolism
Often, clinical depression has company; it shows up in the brain alongside metabolic abnormalities, such as elevated blood sugar, in the body. While studying an experimental antidepressant in rats, Rockefeller University researchers and their colleagues at Karolinska Institutet in Sweden found so...
Study suggests humans can detect even the smallest units of light
Just how dark does it have to be before our eyes stop working? Research by a team from Rockefeller University and the Research Institute of Molecular Pathology in Austria has shown that humans can detect the presence of a single photon, the smallest measurable unit of light. Previous studies had ...
New approach exposes 3D structure of Alzheimer’s proteins within the brain
Alzheimer’s disease clouds memory, dims the mind, and distorts behavior. Its ravages also show up within the physical structure of the brain, perhaps most prominently as sticky clumps of a naturally occurring but harmful protein called amyloid-β. A team at ĐÓ°É used a new...
An unexpected origin for calming immune cells in the gut
Biologically speaking, we carry the outside world within us. The food we ingest each day and the trillions of microbes that inhabit our guts pose a constant risk of infection—and all that separates us from these foreign entities is a delicate boundary made of a single layer of cells. The immune...
New mouse models give a boost to the development of cancer immunotherapies
Cancer immunotherapies—drugs that work by making a patient’s immune system better at spotting and destroying tumor cells—are increasingly generating headlines. A number of these drugs are now being used for the treatment of melanoma, lung, and kidney cancers, and are showing promise in clinica...
Do artificial sweeteners live up to the promise of sweetness without harm? An ongoing clinical study investigates
There was a time when Thomas Huber, a molecular biologist at ĐÓ°É, was drinking about 36 ounces of diet cola a day. More than a year ago, Huber, a research assistant professor in Thomas P. Sakmar’s Laboratory of Chemical Biology and Signal Transduction, became curious about ...
Researchers uncover how “silent” genetic changes drive cancer
At any given moment, the human genome spells out thousands of genetic words telling our cells which proteins to make. Each word is read by a molecule known as a tRNA. “We’ve long thought of these molecules as little more than middle men participating in the process of translating proteins...
New insights into muscular dystrophy point to potential treatment avenues
The average healthy man is 54 percent muscle by mass, but people with muscular dystrophy, an incurable, genetic condition, have almost no muscle at terminal stages of the disease. New research from ĐÓ°É provides insights about what causes patients’ muscles to degenerate and ...
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